Randomised clinical trials (RCTs) remain the gold standard in evaluating therapeutic interventions, ensuring that treatment effects are not confounded by systematic errors. Central to these trials is ...

Results from single-arm clinical trials can be contextualized by comparing against external controls (ECs) derived from real-world data (RWD). However, lack of randomization and differences in ...

Psilocybin trials show poorer control group outcomes compared to SSRIs and esketamine, potentially inflating perceived efficacy due to expectancy bias and functional unblinding. Control group response ...

Psychiatric drugs are reported to be about 50% more effective in clinical trials funded by the drug's manufacturer than when trials of the same drug are sponsored by other groups, new research shows.