Funding to support Phase 1 clinical development of best-in-class PARG inhibitor candidate FORX-428FORX-428 is potential new ...

DNA can sustain serious injuries called double strand breaks, in which both strands of the helix snap. These breaks are among ...

Results from a VHIO-led study show that MYC targeting by Omomyc induces tumor DNA damage in patient-derived preclinical ...

“Our lab is generally interested in discovering and characterizing previously unknown or poorly understood factors that are essential for genome maintenance. This is particularly important in the ...

Cells are not immortal, and that is a good thing. After a certain number of divisions, many human cells stop multiplying for ...

TY1 enhances the action of TREX1, a gene that helps immune cells clear damaged DNA, helping to minimize scar tissue post heart attacks.

There is significant crosstalk between DNA damage response (DDR) pathways and innate immune pathways. Both the individual pathways and their interactions are key areas of interest for the development ...

A noninvasive blood test to detect genetic material shed by tumors may help clinicians identify adverse events related to ...

Tackling a common childhood virus could open the door to preventing bladder cancer, according to new research.