The effectiveness of non-clinical drug safety predictions is enhanced by the adoption of three-dimensional (3D) cellular models. 3D bioprinting enables the generation of complex models with spatial ...

For decades, animal models have been the gold standard for preclinical testing of potential drugs. Yet, even the best animal models are not perfect. For example, small rodent species with engrafted ...

CINCINNATI—Researchers at Cincinnati Children’s Hospital Medical Center in collaboration with Roche, have developed a next-generation human liver organoid microarray platform that that could help ...

In a new study, researchers from Institute of Science Tokyo, Japan, have utilized bile acids as farnesoid X receptor agonists to develop unique hepatic organoids that are capable of sustained, ...

A new human liver organoid microarray developed by Cincinnati Children’s and Roche recreates immune-driven liver injury in the lab. Built from patient-derived stem cells and immune cells, it ...

The authors provide a useful integrated analytical approach to investigating MASLD focused on diverse multiomic integration methods. The strength of evidence for this new resource is solid, as ...

Chronic liver inflammation is one of the most serious complications associated with liver cirrhosis. Researchers from Miguel ...