Fierce Biotech

FDA steers cancer CAR-T developers toward randomized superiority trials in policy shift

The FDA is raising the bar for approval of CAR T-cell therapies in oncology. | The FDA is raising the bar for approval of CAR ...
BioSpace

CAR-T Developers Will Need Randomized Trials as FDA Eyes Tighter Approval Requirements

For traditional approval, CAR T therapies will need to establish superiority over current standard treatments, including ...
Hosted on MSN

Randomized trials show no evidence of non-specific vaccine effects

For more than three decades, researchers Christine Stabell Benn and Peter Aaby from the Bandim Health Project have conducted randomized trials involving thousands of children in Guinea-Bissau and ...
BMJ

Running is acceptable and efficacious in adults with non-specific chronic low back pain: the ASTEROID randomised controlled trial

Objectives Running is one of the most accessible forms of exercise, yet its suitability for adults with chronic low back pain (LBP) is unknown. This study assessed the efficacy and acceptability of ...
BMJ

Exercise training and resting blood pressure: a large-scale pairwise and network meta-analysis of randomised controlled trials

Objective To perform a large-scale pairwise and network meta-analysis on the effects of all relevant exercise training modes on resting blood pressure to establish optimal antihypertensive exercise ...
Thorax

Blood eosinophil-guided systemic corticosteroid duration in adults hospitalised for asthma exacerbation: a randomised, controlled, open-label, non-inferiority trial

Objective Systemic corticosteroids for 5–7 days are standard care for asthma exacerbations, but the optimal duration and ...