Serum lactate gained notoriety in critical care as a potential marker for tissue hypoxia and anaerobic metabolism among patients. With some differences, organizations including the Society of Critical ...

Why is a blood lactate of 14 mmol/L in a patient with trauma not necessarily associated with a poor overall prognosis, while a lactate of similar magnitude in septic shock is associated with a very ...

Integrating lactate assessment with blood pressure evaluation may improve early risk stratification for in-hospital mortality in critically ill adults with COVID-19, as higher lactate concentrations ...

Methanol is an ideal feedstock for bio-manufacturing. Converting it into lactate, a monomer for biodegradable plastic, offers a promising strategy for addressing the challenge of white pollution.

Mitochondrial DNA (mtDNA) mutations impair OXPHOS and enhance lactate accumulation in skeletal muscle. Elevated lactate drives H3K14 histone lactylation, inducing GDF15 expression and secretion in ...

When runners talk physiology, two terms tend to dominate the conversation: VO2 max and lactate threshold. Although the two metrics are related, they are not the same – and they shape performance in ...

Lactate clearance can be used to predict survival in patients with cardiogenic shock and aid in management decisions, and experts are calling for establishing lactate clearance as a standardized, ...

Science has confirmed that exercise is good for the brain. It increases blood flow, inhibits stress hormones, and stimulates the release of “feel-good” endorphins. One way exercise is thought to yield ...

Exercise is known to ultimately boost the release of brain-derived neurotrophic factor (BDNF), a hormone essential for brain health. One trigger for the underlying cascade is thought to be increasing ...

Summary: A new study shows that the brain benefits of exercise may be partly replicated with an IV infusion of lactate, the by-product of intense physical activity. Researchers found that such ...

A new review reveals how lactate and its derivative lactylation process drive breast cancer progression, opening new therapeutic possibilities. The study demonstrates that lactate—a metabolic ...